A new test system for the detection of HIV-1 and HIV-2 has been registered
TestGene has registered the kit "HIV-TEST" for detection and differentiation of human immunodeficiency viruses type 1 and 2 (HIV-1 and HIV-2). The analysis is necessary to make a diagnosis of the HIV infection, as well as to choose an antiretroviral therapy regimen.
The highly conserved regions were chosen as a target for diagnostics; all known groups and subtypes of HIV are detected by the analysis.
The test is carried out by real-time RT-PCR in an RNA sample isolated from human blood plasma.
In combination with effective kits for isolation, the kit "HIV-TEST" has sensitivity of at least 20 copies/ml of plasma when isolated from 1000 μl of blood plasma. This is especially important to diagnose the HIV infection in the early stages of the disease.
“It is known that HIV is characterized by a fairly strong molecular genetic polymorphism; several groups and subtypes are currently distinguished. Therefore, it is important to choose highly conserved regions of genomic RNA for diagnosing infections, which was implemented when creating a set of reagents,” said Alexei Solovyov, Head of the PCR Development Department, Associate Professor, Candidate of Biological Sciences.
The PCR test makes it possible to detect even single viral particles and is used in clinical practice in the following cases:
early diagnostics of the HIV infection before the appearance of antibodies (during the seronegative window period);
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